Korean drug firms rush to safe LNP expertise

Korean pharmaceutical firms are racing to develop a lipid nanoparticle (LNP) drug supply expertise, every utilizing a special technique.

These actively pursuing LNP growth are Daewoong Pharmaceutical, Dong-A Socio Holdings, GC Biopharma, and Yuhan Corp.

Korean drugmakers are rushing to develop a lipid nanoparticle (LNP) drug delivery technology.
Korean drugmakers are speeding to develop a lipid nanoparticle (LNP) drug supply expertise.

LNP is a drug supply system key to growing mRNA-based medicine. The expertise drew a lot consideration when drugmakers developed mRNA Covid-19 vaccines utilizing LNP.

On Wednesday, Daewoong Pharmaceutical stated it picked LNP as a promising drug growth expertise for the long run, saying its purpose to develop into a world chief in drug growth expertise by 2030.

To safe LNP expertise, Daewoong stated it might actively push for open collaboration.

Though Daewoong has not had any joint analysis or licensing settlement for LNP expertise up to now, it can search a partnership with an LNP expertise proudly owning firm, Daewoong stated.

Daewoong plans to make use of LNP to find new indications or develop new drug varieties.

Extra particularly, the corporate goals to develop a “selective organ focused LNP” to focus on particular organs just like the lung or the mind and take a look at numerous new drug varieties reminiscent of oral administration and ocular injection.

Daewoong additionally stated it might enhance the bodily properties of medicine to boost the security of LNP and make medicines straightforward to retailer for a very long time.

Dong-A Socio Holdings has taken fast steps to work on LNP expertise because the outbreak of the Covid-19 pandemic.

ST Pharm, an affiliate of Dong-A Socio Group, signed an settlement with Ewha Womans College Business-Educational Cooperation Basis to collectively develop an LNP expertise in March final 12 months.

Beneath the settlement, ST Pharm Vice President Yang Joo-sung and Ewha College School of Pharmacy Professor Lee Hyuk-jin will develop an LNP expertise.

ST Pharm will cowl the two-year growth price absolutely. After the event, the corporate and the college will apply for the mental property proper for the LNP expertise collectively.

Via joint analysis with Professor Lee, ST Pharm will use a brand new LNP expertise for drug growth and CDMO (contract growth and manufacturing group) enterprise.

In April, GC Biopharma started its journey to develop an LNP expertise. The corporate signed a growth and possibility settlement with Acuitas Therapeutics, a Canada-based LNP developer, to license the latter’s LNP expertise.

GC Biopharma will use as much as 4 LNP applied sciences owned by Acuitas Therapeutics to develop mRNA vaccines or remedies.

Pfizer’s Covid-19 vaccine Comirnaty additionally used Acuitas’ LNP expertise.

Yuhan additionally stated on June 7 that it agreed with a analysis staff of Professor Lee Joo-youp on the College of Cincinnati to develop a brand new LNP supply expertise. The brand new expertise goals to extend mRNA’s supply to focused tissues.

The analysis staff of the College of Cincinnati famous that they might safe the patentability of a brand new substance and use it to lift the supply effectivity. Researchers have restricted entry to the presently commercialized LNP applied sciences because of patents held by some firms.

Utilizing a brand new mRNA construction and a brand new LNP supply expertise, Yuhan plans to develop immunotherapy that regulates the perform of immune cells.

Within the LNP growth course of, the corporate will contemplate synergy results with different immunotherapy pipelines.

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